The College of Medicine at the University of Baghdad published a master’s thesis in the field of histopathology tagged (Molecular classification of gastric adenocarcinoma based on immunohistochemistry of a sample of Iraqi patients, a clinical-pathological study) by the student Ali Makki Muhammad Jaafar.
The discussion committee consisted of: A. Dr. Alaa Ghani Hussein, A. M. Dr. Manwar Al-Naqqash, A. M. Dr. Israa Ali Hussein, and supervised by A. M. Dr. Sazan Abdul Wahab Mirza.
The study aims to apply immunohistochemistry to the molecular classification of gastric adenocarcinoma based on a list of seven tumor parameters, namely microsatellite instability such as mismatch repair proteins (MLH1-MSH2-MSH6-PMS2), p53, EBV-LMP, and E-cadherin.
Also to evaluate the clinicopathological characteristics such as age, gender, tumor location, type of surgery, tumor pattern morphology, tumor stage, tumor size, metastasis, nodal and lymphoma, grade of differentiated tumor, lymphovascular invasion) for these subtypes according to the Cancer Genome Atlas (TCGA) and the Asian Cancer Consortium (ACRG) Molecular Classification.
It was concluded from the study that immunohistochemical analysis can be used to distinguish immunophenotypic groups of gastric adenocarcinoma with distinct clinicopathological characteristics. Therefore, this study shows that gastric adenocarcinoma can be classified into biologically and clinically different subgroups using simple methods that are also applicable to clinical diagnosis.
The student was awarded a grade of distinction after conducting a public discussion of his thesis, and taking into consideration his use of scientific references and discussion.
